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Nuclear PTEN regulates the APC-CDH1 tumor suppressive complex in a phosphatase-independent manner
PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K-AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor suppressive activity, however its nuclear function remains p...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249980/ https://ncbi.nlm.nih.gov/pubmed/21241890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.12.020 |
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