Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent degradation by the 26S proteasome. Notably, emerging evidence suggested that Cdh1 could also f...

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Published in:Cell Discov
Main Authors: Liu, Jia, Wan, Lixin, Liu, Jing, Yuan, Zhu, Zhang, Jinfang, Guo, Jianfeng, Malumbres, Marcos, Liu, Jiankang, Zou, Weiguo, Wei, Wenyi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860961/
https://ncbi.nlm.nih.gov/pubmed/27462441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.44
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