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WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice
The tumor suppressor phosphatase and tensin homolog (PTEN) plays a central role in regulating phosphatidylinositol 3-kinase (PI3K) signaling, and its gene is very frequently mutated in various human cancers. Numerous studies have revealed that PTEN levels are tightly regulated by both transcriptiona...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995496/ https://ncbi.nlm.nih.gov/pubmed/29685889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001060 |
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