WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice

The tumor suppressor phosphatase and tensin homolog (PTEN) plays a central role in regulating phosphatidylinositol 3-kinase (PI3K) signaling, and its gene is very frequently mutated in various human cancers. Numerous studies have revealed that PTEN levels are tightly regulated by both transcriptiona...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Li, Hongchang, Zhang, Pengfei, Zhang, Qiuyue, Li, Chaonan, Zou, Weiguo, Chang, Zhijie, Cui, Chun-Ping, Zhang, Lingqiang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995496/
https://ncbi.nlm.nih.gov/pubmed/29685889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001060
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