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WWP2 is an E3 ubiquitin ligase for PTEN
PTEN, a lipid phosphatase, is one of the most frequently mutated tumour suppressors in human cancer. Several recent studies have highlighted the importance of ubiquitylation in regulating PTEN tumour-suppressor function, but the enzymatic machinery required for PTEN ubiquitylation is not clear. In t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926303/ https://ncbi.nlm.nih.gov/pubmed/21532586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2240 |
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