WWP2 is an E3 ubiquitin ligase for PTEN

PTEN, a lipid phosphatase, is one of the most frequently mutated tumour suppressors in human cancer. Several recent studies have highlighted the importance of ubiquitylation in regulating PTEN tumour-suppressor function, but the enzymatic machinery required for PTEN ubiquitylation is not clear. In t...

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Autori principali: Maddika, Subbareddy, Kavela, Sridhar, Rani, Neelam, Palicharla, Vivek Reddy, Pokorny, Jenny L., Sarkaria, Jann N., Chen, Junjie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926303/
https://ncbi.nlm.nih.gov/pubmed/21532586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2240
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