Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis...

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Главные авторы: Menendez, Javier A., Cufí, Sílvia, Oliveras-Ferraros, Cristina, Martin-Castillo, Begoña, Joven, Jorge, Vellon, Luciano, Vazquez-Martin, Alejandro
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2011
Предметы:
Research Perspective
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249452/
https://ncbi.nlm.nih.gov/pubmed/22170748
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