Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Menendez, Javier A., Cufí, Sílvia, Oliveras-Ferraros, Cristina, Martin-Castillo, Begoña, Joven, Jorge, Vellon, Luciano, Vazquez-Martin, Alejandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2011
Pynciau:
Research Perspective
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249452/
https://ncbi.nlm.nih.gov/pubmed/22170748
Tagiau: Ychwanegu Tag
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