Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

Metabolomic fingerprint of breast cancer cells treated with the antidiabetic drug metformin revealed a significant accumulation of 5-formimino-tetrahydrofolate, one of the tetrahydrofolate forms carrying activated one-carbon units that are essential for the de novo synthesis of purines and pyrimidin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Corominas-Faja, Bruna, Quirantes-Piné, Rosa, Oliveras-Ferraros, Cristina, Vazquez-Martin, Alejandro, Cufí, Sílvia, Martin-Castillo, Begoña, Micol, Vicente, Joven, Jorge, Segura-Carretero, Antonio, Menendez, Javier A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2012
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433934/
https://ncbi.nlm.nih.gov/pubmed/22837425
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak