Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

Metabolomic fingerprint of breast cancer cells treated with the antidiabetic drug metformin revealed a significant accumulation of 5-formimino-tetrahydrofolate, one of the tetrahydrofolate forms carrying activated one-carbon units that are essential for the de novo synthesis of purines and pyrimidin...

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Detalhes bibliográficos
Main Authors: Corominas-Faja, Bruna, Quirantes-Piné, Rosa, Oliveras-Ferraros, Cristina, Vazquez-Martin, Alejandro, Cufí, Sílvia, Martin-Castillo, Begoña, Micol, Vicente, Joven, Jorge, Segura-Carretero, Antonio, Menendez, Javier A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433934/
https://ncbi.nlm.nih.gov/pubmed/22837425
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