Metformin-induced preferential killing of breast cancer initiating CD44(+)CD24(−/low) cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts

Trastuzumab-refractory breast cancer stem cells (CSCs) could explain the high rate of primary resistance to single-agent trastuzumab in HER2 gene-amplified breast cancer patients. The identification of agents with strong selective toxicity for trastuzumab-resistant breast CSCs may have tremendous re...

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Detalhes bibliográficos
Main Authors: Cufí, Sílvia, Corominas-Faja, Bruna, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Dorca, Joan, Bosch-Barrera, Joaquim, Martin-Castillo, Begoña, Menendez, Javier A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380574/
https://ncbi.nlm.nih.gov/pubmed/22565037
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