Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)

The rate of inherent resistance to single-agent trastuzumab in HER2-overexpressing metastatic breast carcinomas is impressive at above 70%. Unfortunately, little is known regarding the distinctive genetic signatures that could predict trastuzumab refractoriness ab initio. The epithelial-to-mesenchym...

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Main Authors: Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Cufí, Sílvia, Vazquez-Martin, Alejandro, Martin-Castillo, Begoña, Iglesias, Juan Manuel, López-Bonet, Eugeni, Martin, Ángel G., Menendez, Javier A.
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507497/
https://ncbi.nlm.nih.gov/pubmed/22992620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22225
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