Basal/HER2 breast carcinomas: Integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin)

High rates of inherent primary resistance to the humanized monoclonal antibody trastuzumab (Herceptin) are frequent among HER2 gene-amplified breast carcinomas in both metastatic and adjuvant settings. The clinical efficacy of trastuzumab is highly correlated with its ability to specifically and eff...

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Bibliographic Details
Main Authors: Martin-Castillo, Begoña, Oliveras-Ferraros, Cristina, Vazquez-Martin, Alejandro, Cufí, Silvia, Moreno, José Manuel, Corominas-Faja, Bruna, Urruticoechea, Ander, Martín, Ángel G., López-Bonet, Eugeni, Menendez, Javier A.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575452/
https://ncbi.nlm.nih.gov/pubmed/23255137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23274
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