Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

The enrichment of cancer stem cell (CSC)-like cellular states has not previously been considered to be a causative mechanism in the generalized progression of EGFR-mutant non-small cell lung carcinomas (NSCLC) after an initial response to the EGFR tyrosine kinase inhibitor erlotinib. To explore this...

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Bibliographische Detailangaben
Hauptverfasser: Corominas-Faja, Bruna, Oliveras-Ferraros, Cristina, Cuyàs, Elisabet, Segura-Carretero, Antonio, Joven, Jorge, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Micol, Vicente, Bosch-Barrera, Joaquim, Menendez, Javier A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895428/
https://ncbi.nlm.nih.gov/pubmed/24047698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26417
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