IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

Using non-small cell lung carcinoma (NSCLC) cells harboring the erlotinib-sensitizing Epidermal Growth Factor Receptor (EGFR) exon 19 mutation delE746-A750, we developed erlotinib-refractory derivatives in which hyperactive Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling associated with enr...

Full description

Saved in:
Bibliographic Details
Main Authors: Vazquez-Martin, Alejandro, Cufí, Sílvia, Oliveras-Ferraros, Cristina, Torres-Garcia, Violeta Zenobia, Corominas-Faja, Bruna, Cuyàs, Elisabet, Bonavia, Rosa, Visa, Joana, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Micol, Vicente, Bosch-Barrera, Joaquim, Menendez, Javier A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759044/
https://ncbi.nlm.nih.gov/pubmed/23994953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02560
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items