Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinogenesis. Herein, we present the new hypothesis...

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Bibliographische Detailangaben
Hauptverfasser: Menendez, Javier A., Cufí, Sílvia, Oliveras-Ferraros, Cristina, Martin-Castillo, Begoña, Joven, Jorge, Vellon, Luciano, Vazquez-Martin, Alejandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2011
Schlagworte:
Research Perspective
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249452/
https://ncbi.nlm.nih.gov/pubmed/22170748
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