Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid

Ample evidence suggests that almost all polypeptides can either adopt a native structure (folded or intrinsically disordered) or form misfolded amyloid fibrils. Soluble protein oligomers exist as an intermediate between these two states, and their cytotoxicity has been implicated in the pathology of...

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Detaylı Bibliyografya
Asıl Yazarlar: Di Domizio, Jeremy, Zhang, Ran, Stagg, Loren J., Gagea, Mihai, Zhuo, Ming, Ladbury, John E., Cao, Wei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249128/
https://ncbi.nlm.nih.gov/pubmed/22102410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238477
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