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Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid

Ample evidence suggests that almost all polypeptides can either adopt a native structure (folded or intrinsically disordered) or form misfolded amyloid fibrils. Soluble protein oligomers exist as an intermediate between these two states, and their cytotoxicity has been implicated in the pathology of...

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書誌詳細
主要な著者: Di Domizio, Jeremy, Zhang, Ran, Stagg, Loren J., Gagea, Mihai, Zhuo, Ming, Ladbury, John E., Cao, Wei
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249128/
https://ncbi.nlm.nih.gov/pubmed/22102410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238477
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