Role of Glycosaminoglycan Sulfation in the Formation of Immunoglobulin Light Chain Amyloid Oligomers and Fibrils

Primary amyloidosis (AL) results from overproduction of unstable monoclonal immunoglobulin light chains (LCs) and the deposition of insoluble fibrils in tissues, leading to fatal organ disease. Glycosaminoglycans (GAGs) are associated with AL fibrils and have been successfully targeted in the treatm...

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Detaylı Bibliyografya
Asıl Yazarlar: Ren, Ruiyi, Hong, Zhenning, Gong, Haiyan, Laporte, Kate, Skinner, Martha, Seldin, David C., Costello, Catherine E., Connors, Lawreen H., Trinkaus-Randall, Vickery
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988372/
https://ncbi.nlm.nih.gov/pubmed/20870723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149575
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