Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis

Systemic AL amyloidosis results from the aggregation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell clone in the bone marrow. AL is the most rapidly fatal of the systemic amyloidoses, as amyloid fibrils can rapidly accumulate in tissues including the heart...

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Main Authors: Ward, Jennifer Ellis, Ren, Ruiyi, Toraldo, Gianluca, SooHoo, Pam, Guan, Jian, O'Hara, Carl, Jasuja, Ravi, Trinkaus-Randall, Vickery, Liao, Ronglih, Connors, Lawreen H., Seldin, David C.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242721/
https://ncbi.nlm.nih.gov/pubmed/21998211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-351643
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