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Preclinical Development of siRNA Therapeutics for AL Amyloidosis
AL (amyloid light chain) amyloidosis is a rare hematologic disorder characterized by the accumulation of a misfolded monoclonal immunoglobulin light chain (LC) as fibrillar protein deposits. Current treatments, including cytotoxic chemotherapy and immunomodulatory therapy, are directed at killing th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155733/ https://ncbi.nlm.nih.gov/pubmed/21562591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.69 |
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