Preclinical Development of siRNA Therapeutics for AL Amyloidosis

AL (amyloid light chain) amyloidosis is a rare hematologic disorder characterized by the accumulation of a misfolded monoclonal immunoglobulin light chain (LC) as fibrillar protein deposits. Current treatments, including cytotoxic chemotherapy and immunomodulatory therapy, are directed at killing th...

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Bibliografski detalji
Glavni autori: Hovey, Beth M., Ward, Jennifer E., Hoo, Pamela Soo, O’Hara, Carl J., Connors, Lawreen H., Seldin, David C.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155733/
https://ncbi.nlm.nih.gov/pubmed/21562591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.69
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