Role of Glycosaminoglycan Sulfation in the Formation of Immunoglobulin Light Chain Amyloid Oligomers and Fibrils

Primary amyloidosis (AL) results from overproduction of unstable monoclonal immunoglobulin light chains (LCs) and the deposition of insoluble fibrils in tissues, leading to fatal organ disease. Glycosaminoglycans (GAGs) are associated with AL fibrils and have been successfully targeted in the treatm...

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Autori principali: Ren, Ruiyi, Hong, Zhenning, Gong, Haiyan, Laporte, Kate, Skinner, Martha, Seldin, David C., Costello, Catherine E., Connors, Lawreen H., Trinkaus-Randall, Vickery
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988372/
https://ncbi.nlm.nih.gov/pubmed/20870723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149575
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