Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid

Ample evidence suggests that almost all polypeptides can either adopt a native structure (folded or intrinsically disordered) or form misfolded amyloid fibrils. Soluble protein oligomers exist as an intermediate between these two states, and their cytotoxicity has been implicated in the pathology of...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Di Domizio, Jeremy, Zhang, Ran, Stagg, Loren J., Gagea, Mihai, Zhuo, Ming, Ladbury, John E., Cao, Wei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249128/
https://ncbi.nlm.nih.gov/pubmed/22102410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238477
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker