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Binding with Nucleic Acids or Glycosaminoglycans Converts Soluble Protein Oligomers to Amyloid
Ample evidence suggests that almost all polypeptides can either adopt a native structure (folded or intrinsically disordered) or form misfolded amyloid fibrils. Soluble protein oligomers exist as an intermediate between these two states, and their cytotoxicity has been implicated in the pathology of...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249128/ https://ncbi.nlm.nih.gov/pubmed/22102410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238477 |
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