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Endosomal Accumulation of the Activated Epidermal Growth Factor Receptor (EGFR) Induces Apoptosis

Endocytosis positively and negatively regulates cell surface receptor signaling by temporally and spatially controlling interactions with downstream effectors. This process controls receptor-effector communication. However, the relationship between receptor endocytic trafficking and cell physiology...

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Autores principales: Rush, Jamie S., Quinalty, Leslie M., Engelman, Luke, Sherry, David M., Ceresa, Brian P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249126/
https://ncbi.nlm.nih.gov/pubmed/22102283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.294470
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