Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells

The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux). The interaction energies involved in binding of suc...

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Bibliographische Detailangaben
Hauptverfasser: Wildling, Linda, Rankl, Christian, Haselgrübler, Thomas, Gruber, Hermann J., Holy, Marion, Newman, Amy Hauck, Zou, Mu-Fa, Zhu, Rong, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249061/
https://ncbi.nlm.nih.gov/pubmed/22033932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304873
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