Nanopharmacological force sensing reveals allosteric coupling in transporter binding sites

Controversy regarding the number and function of ligand binding sites in neurotransmitter/sodium symporters arose from conflicting data in crystal structures and molecular pharmacology. Here, we designed novel tools for atomic force microscopy that directly measure the interaction forces between the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Angew Chem Int Ed Engl
Prif Awduron: Zhu, Rong, Sinwel, Doris, Hasenhuetl, Peter S., Saha, Kusumika, Kumar, Vivek, Zhang, Peng, Rankl, Christian, Holy, Marion, Sucic, Sonja, Kudlacek, Oliver, Karner, Andreas, Sandtner, Walter, Stockner, Thomas, Gruber, Hermann J., Freissmuth, Michael, Newman, Amy Hauck, Sitte, Harald H., Hinterdorfer, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932834/
https://ncbi.nlm.nih.gov/pubmed/26695726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508755
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