Nanopharmacological force sensing reveals allosteric coupling in transporter binding sites

Controversy regarding the number and function of ligand binding sites in neurotransmitter/sodium symporters arose from conflicting data in crystal structures and molecular pharmacology. Here, we designed novel tools for atomic force microscopy that directly measure the interaction forces between the...

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Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhu, Rong, Sinwel, Doris, Hasenhuetl, Peter S., Saha, Kusumika, Kumar, Vivek, Zhang, Peng, Rankl, Christian, Holy, Marion, Sucic, Sonja, Kudlacek, Oliver, Karner, Andreas, Sandtner, Walter, Stockner, Thomas, Gruber, Hermann J., Freissmuth, Michael, Newman, Amy Hauck, Sitte, Harald H., Hinterdorfer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932834/
https://ncbi.nlm.nih.gov/pubmed/26695726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508755
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