Nanopharmacological force sensing reveals allosteric coupling in transporter binding sites

Controversy regarding the number and function of ligand binding sites in neurotransmitter/sodium symporters arose from conflicting data in crystal structures and molecular pharmacology. Here, we designed novel tools for atomic force microscopy that directly measure the interaction forces between the...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Angew Chem Int Ed Engl
Päätekijät: Zhu, Rong, Sinwel, Doris, Hasenhuetl, Peter S., Saha, Kusumika, Kumar, Vivek, Zhang, Peng, Rankl, Christian, Holy, Marion, Sucic, Sonja, Kudlacek, Oliver, Karner, Andreas, Sandtner, Walter, Stockner, Thomas, Gruber, Hermann J., Freissmuth, Michael, Newman, Amy Hauck, Sitte, Harald H., Hinterdorfer, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932834/
https://ncbi.nlm.nih.gov/pubmed/26695726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508755
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