Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in a physiological setting by designing novel to...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Zhu, Rong, Sandtner, Walter, Ahiable, Joan E. A., Newman, Amy Hauck, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325972/
https://ncbi.nlm.nih.gov/pubmed/32656227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00099
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