Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in a physiological setting by designing novel to...

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Bibliografski detalji
Izdano u:Front Mol Biosci
Glavni autori: Zhu, Rong, Sandtner, Walter, Ahiable, Joan E. A., Newman, Amy Hauck, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Molecular Biosciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325972/
https://ncbi.nlm.nih.gov/pubmed/32656227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00099
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