Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in a physiological setting by designing novel to...

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Publicat a:Front Mol Biosci
Autors principals: Zhu, Rong, Sandtner, Walter, Ahiable, Joan E. A., Newman, Amy Hauck, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Molecular Biosciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325972/
https://ncbi.nlm.nih.gov/pubmed/32656227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00099
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