Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells

The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux). The interaction energies involved in binding of suc...

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Main Authors: Wildling, Linda, Rankl, Christian, Haselgrübler, Thomas, Gruber, Hermann J., Holy, Marion, Newman, Amy Hauck, Zou, Mu-Fa, Zhu, Rong, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249061/
https://ncbi.nlm.nih.gov/pubmed/22033932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304873
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