The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine binding to SERT increases accessibility in the permeat...

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Detaylı Bibliyografya
Asıl Yazarlar: Bulling, Simon, Schicker, Klaus, Zhang, Yuan-Wei, Steinkellner, Thomas, Stockner, Thomas, Gruber, Christian W., Boehm, Stefan, Freissmuth, Michael, Rudnick, Gary, Sitte, Harald H., Sandtner, Walter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365767/
https://ncbi.nlm.nih.gov/pubmed/22451652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343681
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