The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine binding to SERT increases accessibility in the permeat...

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Bibliografiska uppgifter
Huvudupphovsmän: Bulling, Simon, Schicker, Klaus, Zhang, Yuan-Wei, Steinkellner, Thomas, Stockner, Thomas, Gruber, Christian W., Boehm, Stefan, Freissmuth, Michael, Rudnick, Gary, Sitte, Harald H., Sandtner, Walter
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Molecular Biophysics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365767/
https://ncbi.nlm.nih.gov/pubmed/22451652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343681
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