The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine binding to SERT increases accessibility in the permeat...

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Détails bibliographiques
Auteurs principaux: Bulling, Simon, Schicker, Klaus, Zhang, Yuan-Wei, Steinkellner, Thomas, Stockner, Thomas, Gruber, Christian W., Boehm, Stefan, Freissmuth, Michael, Rudnick, Gary, Sitte, Harald H., Sandtner, Walter
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365767/
https://ncbi.nlm.nih.gov/pubmed/22451652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343681
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