The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine binding to SERT increases accessibility in the permeat...

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Main Authors: Bulling, Simon, Schicker, Klaus, Zhang, Yuan-Wei, Steinkellner, Thomas, Stockner, Thomas, Gruber, Christian W., Boehm, Stefan, Freissmuth, Michael, Rudnick, Gary, Sitte, Harald H., Sandtner, Walter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365767/
https://ncbi.nlm.nih.gov/pubmed/22451652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343681
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