Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions

Coupling of spindle orientation to cellular polarity is a prerequisite for epithelial asymmetric cell divisions. The current view posits that the adaptor Inscuteable (Insc) bridges between Par3 and the spindle tethering machinery assembled on NuMA∶LGN∶Gαi(GDP), thus triggering apico-basal spindle or...

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Main Authors: Culurgioni, Simone, Alfieri, Andrea, Pendolino, Valentina, Laddomada, Federica, Mapelli, Marina
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248549/
https://ncbi.nlm.nih.gov/pubmed/22171003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113077108
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