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Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions

Coupling of spindle orientation to cellular polarity is a prerequisite for epithelial asymmetric cell divisions. The current view posits that the adaptor Inscuteable (Insc) bridges between Par3 and the spindle tethering machinery assembled on NuMA∶LGN∶Gαi(GDP), thus triggering apico-basal spindle or...

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Bibliografski detalji
Glavni autori: Culurgioni, Simone, Alfieri, Andrea, Pendolino, Valentina, Laddomada, Federica, Mapelli, Marina
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248549/
https://ncbi.nlm.nih.gov/pubmed/22171003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113077108
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