Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction

Immunotherapies targeting peptides presented by allogeneic MHC molecules offer the prospect of circumventing tolerance to key tumor-associated self-antigens. However, the degree of antigen specificity mediated by alloreactive T cells, and their ability to discriminate normal tissues from transformed...

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Bibliografiset tiedot
Päätekijät: Simpson, Amy A., Mohammed, Fiyaz, Salim, Mahboob, Tranter, Amy, Rickinson, Alan B., Stauss, Hans J., Moss, Paul A. H., Steven, Neil M., Willcox, Benjamin E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2011
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248497/
https://ncbi.nlm.nih.gov/pubmed/22160697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108422109
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