Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition

T cell recognition of minor histocompatibility antigens (mHags) underlies allogeneic immune responses that mediate graft-versus-host disease and the graft-versus-leukemia effect following stem cell transplantation. Many mHags derive from single amino acid polymorphisms in MHC-restricted epitopes, bu...

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Detalhes bibliográficos
Main Authors: Nicholls, Sarah, Piper, Karen P., Mohammed, Fiyaz, Dafforn, Timothy R., Tenzer, Stefan, Salim, Mahboob, Mahendra, Premini, Craddock, Charles, van Endert, Peter, Schild, Hansjörg, Cobbold, Mark, Engelhard, Victor H., Moss, Paul A. H., Willcox, Benjamin E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656175/
https://ncbi.nlm.nih.gov/pubmed/19234124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900411106
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