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Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity

BACKGROUND: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide binding prediction have largely concentrated o...

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Detalhes bibliográficos
Main Authors: Davies, Matthew N, Hattotuwagama, Channa K, Moss, David S, Drew, Michael GB, Flower, Darren R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435758/
https://ncbi.nlm.nih.gov/pubmed/16549002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-6-5
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