Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

BACKGROUND: Amyloid β (Aβ) accumulates in Alzheimer's disease (AD) brain. Microglial activation also occurs in AD, and this inflammatory response may contribute to disease progression. Microglial activation can be induced by Aβ, but the mechanisms by which this occurs have not been defined. The...

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Autori principali: Kauppinen, Tiina M, Suh, Sang Won, Higashi, Youichirou, Berman, Ari E, Escartin, Carole, Won, Seok Joon, Wang, Chao, Cho, Seo-Hyun, Gan, Li, Swanson, Raymond A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247192/
https://ncbi.nlm.nih.gov/pubmed/22051244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-152
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