Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2

Sustained activation of poly(ADP-ribose) polymerase-1 (PARP-1) and extracellular signal-regulated kinases 1/2 (ERK1/2) both promote neuronal death. Here we identify a direct link between these two cell death pathways. In a rat model of hypoglycemic brain injury, neuronal PARP-1 activation and subseq...

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Библиографические подробности
Главные авторы: Kauppinen, Tiina M., Chan, Wai Y., Suh, Sang Won, Wiggins, Amanda K., Huang, Eric J., Swanson, Raymond A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459030/
https://ncbi.nlm.nih.gov/pubmed/16627622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508606103
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