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Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations

Poly(ADP-ribose) polymerase-1 (PARP-1), when activated by DNA damage, promotes both cell death and inflammation. Here we report that PARP-1 enzymatic activity is directly inhibited by minocycline and other tetracycline derivatives that have previously been shown to have neuroprotective and anti-infl...

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Bibliographische Detailangaben
Hauptverfasser: Alano, Conrad C., Kauppinen, Tiina M., Valls, Andreu Viader, Swanson, Raymond A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480467/
https://ncbi.nlm.nih.gov/pubmed/16769901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600554103
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