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Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
Poly(ADP-ribose) polymerase-1 (PARP-1), when activated by DNA damage, promotes both cell death and inflammation. Here we report that PARP-1 enzymatic activity is directly inhibited by minocycline and other tetracycline derivatives that have previously been shown to have neuroprotective and anti-infl...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1480467/ https://ncbi.nlm.nih.gov/pubmed/16769901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600554103 |
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