Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

BACKGROUND: Amyloid β (Aβ) accumulates in Alzheimer's disease (AD) brain. Microglial activation also occurs in AD, and this inflammatory response may contribute to disease progression. Microglial activation can be induced by Aβ, but the mechanisms by which this occurs have not been defined. The...

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Autors principals: Kauppinen, Tiina M, Suh, Sang Won, Higashi, Youichirou, Berman, Ari E, Escartin, Carole, Won, Seok Joon, Wang, Chao, Cho, Seo-Hyun, Gan, Li, Swanson, Raymond A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247192/
https://ncbi.nlm.nih.gov/pubmed/22051244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-152
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