Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

The protein PCSK9 (proprotein convertase subtilisin/kexin type 9) is a key regulator of low-density lipoprotein receptor (LDLR) levels and cardiovascular health. We have determined the crystal structure of LDLR bound to PCSK9 at neutral pH. The structure shows LDLR in a new extended conformation. Th...

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Bibliographische Detailangaben
Hauptverfasser: Surdo, Paola Lo, Bottomley, Matthew J, Calzetta, Alessandra, Settembre, Ethan C, Cirillo, Agostino, Pandit, Shilpa, Ni, Yan G, Hubbard, Brian, Sitlani, Ayesha, Carfí, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Scientific Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245695/
https://ncbi.nlm.nih.gov/pubmed/22081141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.205
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