A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

PCSK9 binds to the low density lipoprotein receptor (LDLR) and leads to LDLR degradation and inhibition of plasma LDL cholesterol clearance. Consequently, the role of PCSK9 in modulating circulating LDL makes it a promising therapeutic target for treating hypercholesterolemia and coronary heart dise...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ni, Yan G., Condra, Jon H., Orsatti, Laura, Shen, Xun, Di Marco, Stefania, Pandit, Shilpa, Bottomley, Matthew J., Ruggeri, Lionello, Cummings, Richard T., Cubbon, Rose M., Santoro, Joseph C., Ehrhardt, Anka, Lewis, Dale, Fisher, Timothy S., Ha, Sookhee, Njimoluh, Leila, Wood, Dana D., Hammond, Holly A., Wisniewski, Douglas, Volpari, Cinzia, Noto, Alessia, Lo Surdo, Paola, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857140/
https://ncbi.nlm.nih.gov/pubmed/20172854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113035
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados