A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

PCSK9 binds to the low density lipoprotein receptor (LDLR) and leads to LDLR degradation and inhibition of plasma LDL cholesterol clearance. Consequently, the role of PCSK9 in modulating circulating LDL makes it a promising therapeutic target for treating hypercholesterolemia and coronary heart dise...

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Hlavní autoři: Ni, Yan G., Condra, Jon H., Orsatti, Laura, Shen, Xun, Di Marco, Stefania, Pandit, Shilpa, Bottomley, Matthew J., Ruggeri, Lionello, Cummings, Richard T., Cubbon, Rose M., Santoro, Joseph C., Ehrhardt, Anka, Lewis, Dale, Fisher, Timothy S., Ha, Sookhee, Njimoluh, Leila, Wood, Dana D., Hammond, Holly A., Wisniewski, Douglas, Volpari, Cinzia, Noto, Alessia, Lo Surdo, Paola, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857140/
https://ncbi.nlm.nih.gov/pubmed/20172854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113035
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