Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

Successful development of drugs against novel targets crucially depends on reliable identification of the activity of the target gene product in vivo and a clear demonstration of its specific functional role for disease development. Here, we describe an immunological knockdown (IKD) method, a novel...

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Main Authors: Fattori, Elena, Cappelletti, Manuela, Lo Surdo, Paola, Calzetta, Alessandra, Bendtsen, Claus, Ni, Yan G., Pandit, Shilpa, Sitlani, Ayesha, Mesiti, Giuseppe, Carfí, Andrea, Monaci, Paolo
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540849/
https://ncbi.nlm.nih.gov/pubmed/22611251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M028340
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