Defining the role of TORC1/2 in multiple myeloma

Mammalian target of rapamycin (mTOR) is a downstream serine/threonine kinase of the PI3K/Akt pathway that integrates signals from the tumor microenvironment to regulate multiple cellular processes. Rapamycin and its analogs have not shown significant activity in multiple myeloma (MM), likely because...

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Bibliographic Details
Main Authors: Maiso, Patricia, Liu, Yi, Morgan, Brittany, Azab, Abdel Kareem, Ren, Pingda, Martin, Michel B., Zhang, Yong, Liu, Yang, Sacco, Antonio, Ngo, Hai, Azab, Feda, Quang, Phong, Rodig, Scott J., Lin, Charles P., Roccaro, Aldo M., Rommel, Christian, Ghobrial, Irene M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245208/
https://ncbi.nlm.nih.gov/pubmed/22045983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-342394
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