Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenström macroglobulinemia

Proteasome inhibition represents a valid antitumor approach and its use has been validated in Waldenström macroglobulinemia (WM), where bortezomib has been successfully tested in clinical trials. Nevertheless, a significant fraction of patients relapses, and many present toxicity due to its off-targ...

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Detalhes bibliográficos
Main Authors: Roccaro, Aldo M., Sacco, Antonio, Aujay, Monette, Ngo, Hai T., Azab, Abdel Kareem, Azab, Feda, Quang, Phong, Maiso, Patricia, Runnels, Judith, Anderson, Kenneth C., Demo, Susan, Ghobrial, Irene M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875093/
https://ncbi.nlm.nih.gov/pubmed/20110419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-243402
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