Defining the role of TORC1/2 in multiple myeloma

Mammalian target of rapamycin (mTOR) is a downstream serine/threonine kinase of the PI3K/Akt pathway that integrates signals from the tumor microenvironment to regulate multiple cellular processes. Rapamycin and its analogs have not shown significant activity in multiple myeloma (MM), likely because...

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Bibliografische gegevens
Hoofdauteurs: Maiso, Patricia, Liu, Yi, Morgan, Brittany, Azab, Abdel Kareem, Ren, Pingda, Martin, Michel B., Zhang, Yong, Liu, Yang, Sacco, Antonio, Ngo, Hai, Azab, Feda, Quang, Phong, Rodig, Scott J., Lin, Charles P., Roccaro, Aldo M., Rommel, Christian, Ghobrial, Irene M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2011
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245208/
https://ncbi.nlm.nih.gov/pubmed/22045983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-342394
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