Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was shown to promote metastasis through activation of proteins involved in the epithelial-mesenchymal transition (EMT) proce...

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Main Authors: Azab, Abdel Kareem, Hu, Jinsong, Quang, Phong, Azab, Feda, Pitsillides, Costas, Awwad, Rana, Thompson, Brian, Maiso, Patricia, Sun, Jessica D., Hart, Charles P., Roccaro, Aldo M., Sacco, Antonio, Ngo, Hai T., Lin, Charles P., Kung, Andrew L., Carrasco, Ruben D., Vanderkerken, Karin, Ghobrial, Irene M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382938/
https://ncbi.nlm.nih.gov/pubmed/22394600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-380410
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