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Synthesis of the 5′-Se-Thymidine Phosphoramidite and Convenient Labeling of DNA Oligonucleotide
[Image: see text] The synthesis of the 5′-Se-derivatized thymidine and phosphoramidite is reported, and the Se-phosphoramidite was incorporated into DNA. Because of its high nucleophilicity, this 5′-Se-moiety permits convenient post-synthetic modification of oligonucleotides. The proof of principle...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241971/ https://ncbi.nlm.nih.gov/pubmed/21434607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200397c |
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