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Synthesis of a 2′-Se-Thymidine Phosphoramidite and Its Incorporation into Oligonucleotides for Crystal Structure Study

To investigate nucleic acids with selenium derivatization for crystallography, we report the first synthesis of 2′-methylseleno-thymidine phosphoramidite and its incorporation into DNAs and RNAs by solid-phase synthesis with over 99% coupling yield. The d(GT(Se)GTACAC)(2) crystal structure was also...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Sheng, Jia, Jiang, Jiansheng, Salon, Jozef, Huang, Zhen
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532523/
https://ncbi.nlm.nih.gov/pubmed/17263541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol062937w
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