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Synthesis of 5-Dihydroxyboryluridine Phosphoramidite and Its Site-Specific Incorporation into Oligonucleotides for Probing Thymine DNA Glycosylase

A concise synthetic strategy to 5-dihydroxyboryldexoyuridine (5boU) phosphoramidite has been developed. 5boU was introduced into short oligonucleotides in a site-specific manner, demonstrating compatibility of the boronic acid moiety with standard solid-phase DNA synthesis chemistry. Electrophilic 5...

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書目詳細資料
發表在:Org Lett
Main Authors: Kavoosi, Sam, Dey, Debasis, Islam, Kabirul
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042053/
https://ncbi.nlm.nih.gov/pubmed/31448618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b02042
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